In cryo-EM, the freezing of the sample is done in ethane slush to produce vitreous, or non-crystalline, ice. The frozen sample grid is then kept at liquid nitrogen temperature in the electron microscope and digital micrographs are collected with a camera.
The advantages of cryo-EM over traditional EM techniques include the preservation of the sample in a near-native hydrated state without the distortions from stains or fixatives needed for traditional EM. With image processing and averaging of multiple images, cryo-EM provides high resolution information.
According to the new market research report “Global Cryo-Electron Microscope Market Report 2023-2029”, published by QYResearch, the global Cryo-Electron Microscope market size is projected to reach USD 0.63 billion by 2029, at a CAGR of 5.4% during the forecast period.
Figure. Global Cryo-Electron Microscope Market Size (US$ Million), 2018-2029
Figure. Global Cryo-Electron Microscope Top 4 Players Ranking and Market Share (Ranking is based on the revenue of 2022, continually updated)

The global key manufacturers of Cryo-Electron Microscope include Thermo Fisher Scientific, JEOL, etc. In 2022, the global top three players had a share approximately 99.0% in terms of revenue.
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